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Curcumin-entrapped in PLGA-PEG nanoparticles conjugated to folic acid (PPF-curcumin) was tested on HeLa cells at 5 μM, showing reduced cell viability, increased cytotoxicity, and chemo sensitization, along with downregulation of NF-κB, p-Akt, p-p38, p-JNK, p-ERK1/2, COX-2, Bcl-2, cyclin D1, XIAP, c-IAP, and survivin [189]

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Patients reported significant improvements in symptoms, including a 43% reduction in daily pelvic pain and a 37% reduction in dysmenorrhea